A significant interaction between treatment group and sex was observed with the following end points: This difference was driven by better performance of the everolimus-eluting stent in women. Baseline demographic and clinical characteristics of all patients are depicted in Table 1. In contrast with men, stent diameter was smaller in women. The use of everolimus-eluting stents may represent an added value in women as it showed a reduced rate of repeated revascularization compared to men. Results Of patients included in the trial, Methods Between and , first myocardial infarction patients were consecutively registered in 6 Spanish hospitals. Conclusions Despite poorer baseline clinical characteristics, women with ST-segment elevation myocardial infarction treated with percutaneous coronary intervention showed outcomes similar to men. The PCI was performed according to the standard medical practice.
The PCI was performed according to the standard medical practice. In contrast with men, stent diameter was smaller in women. Logistic regression and Cox regression were used to determine associations between sex and day or long-term mortality, with adjustment for the confounding variables identified. May Next article Rev Esp Cardiol. Primary end point was combined all-cause death, any recurrent myocardial infarction, and any revascularization. In the multivariate analyses, different models were built to assess the influence on mortality of different sets of variables, such as age and electrocardiogram pattern model 1 , comorbidities model 2 , the severity of AMI model 3 , management medical therapy during admission [for day case-fatality] or at discharge [for intermediate and long term mortality]—model 4a—or invasive procedures—model 4b— , and all mentioned variables model 5. This database, made available by the Spanish Health Ministry to public institutions health care administrations, research centers , provides information on vital status and date of death and can be manually linked with individual patient data in our hospital registries. Women also showed a longer delay in arriving at the hospital after symptom onset. Myocardial necrosis is defined as elevated levels according to the normal levels as defined in each center of troponin T or I, or of the creatine phosphokinase-MB fraction, in the presence of symptoms related to myocardial ischemia. An individual follow-up was performed in all patients most of them with a clinical visit and the rest by phone call to assess day events angina, reinfarction, stroke, death. Conclusions Despite poorer baseline clinical characteristics, women with ST-segment elevation myocardial infarction treated with percutaneous coronary intervention showed outcomes similar to men. After multivariate adjustment, men had higher 7-year mortality than women, hazard ratio 1. These results are observed in both ST-segment elevation myocardial infarction and non-ST-segment elevation myocardial infarction events. Seven-year vital status was also ascertained by data linkage with the National Mortality Index. Baseline Demographic and Clinical Characteristics. Among women, those allocated to BMS had a higher prevalence of prior myocardial infarction and a higher prevalence of smoking. All of the hospital protocols followed national and international clinical practice guidelines in force at the time of the study. The short-term prognosis of a first myocardial infarction in this century is similar in both sexes. Baseline characteristics for each sex were compared using Student t test for continuous variables and chi-square test for categorical variables. Information related to previous smoking and angina was also recorded by self-report. Women were older, fewer were smokers, and they had a higher prevalence of hypertension than men. Results The registry included women and men with a first myocardial infarction. No differences were observed in use of invasive procedures. Cox regression analyses were performed for each end point. Results Of patients included in the trial, Baseline demographic and clinical characteristics of all patients are depicted in Table 1. A significant interaction between treatment group and sex was observed with the following end points:
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